49ers 48-27 Colts (Dec 22, 2025) Game Recap ESPNQB Brock Purdy and RB Christian McCaffrey help lead 49ers past Colts ESPN49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers’ season debut at home in 48-27 win Yahoo Sports49ers vs. Colts MNF Highlights: Purdy’s Career Night… » …
49ers 48-27 Colts (Dec 22, 2025) Game Recap
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