A1c level strongly predicts the risk of developing type 2 diabetes among adolescents with overweight or obesity, new data suggested.
A new study published online on January 17, 2024, in JAMA Network Open by pediatric endocrinologist Francis M. Hoe, MD, of Kaiser Permanente Roseville Medical Center, Roseville, California, and colleagues revealed that the incidence of type 2 diabetes was relatively low overall among adolescents with overweight and obesity. However, the risk increased with baseline A1c levels above 6.0% as well as in those with more severe obesity, women, and Asian or Pacific Islanders.
This is one of the first large population studies to examine the incidence and risk for type 2 diabetes by incremental level of A1c in a racially and ethnically diverse group of youth with overweight and obesity, Hoe told Medscape Medical News in an interview. The researchers also discovered that risk for type 2 diabetes is low in overweight and obese youth, especially those with an HbA1c less than 5.9%.
“This is the largest and cleanest data set used to assess HbA1c and obesity as predictors of incident diabetes, with an advantage of being in a system that provides comprehensive care and with HbA1cs from a central lab,” commented Megan Moriarty Kelsey, MD, Professor of Pediatrics and Medical Director of Lifestyle Medicine and of Adolescent Bariatric Surgery at the Children’s Hospital Colorado, Aurora, in an interview with Medscape Medical News.

